May-Hegglin anomaly

May-Hegglin anomaly.

A 35-year-old woman with known May-Hegglin anomaly (and a positive family history) was seen in a fertility clinic. She was found to have marked thrombocytopenia (16 109/L). The other cell counts were normal. Other than hypothyroidism that was controlled with levothyroxine, she was otherwise healthy with no evidence of bleeding. The peripheral blood film demonstrated the features of May-Hegglin ...

Ultrastructural Studies of the May-Hegglin Anomaly

By S. W. JORDAN AND \V. E. LARSEN I HE INHERITED CONDITION known as the May-Hegghin anomaly is characterized by the occurrence of crescent or spindle-shaped cytoplasmic inclusions containing ribose nucleic acid ( RNA ) in polymorphonuclear leukocytes in combination with platelet abnormalities. May ( 1909) 1 noted the presence of distinctive basophilic, pyroninophilic patches in the cytoplasm of...

Ultrastructure of the May-Hegglin anomaly.

Ultrastructural features of the leucocytes in two patients suffering from the May-Hegglin anomaly were studied using electron microscopy. In both the cases, electron dense material parallel to the long axis of the inclusions were noted. Platelet ultrastructure was normal. A review of the literature indicates that the May-Hegglin anomaly is a heterogeneous condition both ultrastructurally and cl...

Ultrastructural Studies of the May-hegglin Anomaly.

The May-Hegglin anomaly: platelet function, ultrastructure and chromosome studies.

T HE MAY-HEGCLIN ANOMALY is a rare hereditary condition characterized by giant platelets and D#{246}hle inclusion bodies in the granulocytes. May first described the anomaly in 1909,’ and in 1945 Hegglin described the condition in a man and his two sons.2 Subsequent reports have confirmed the familial nature with an autosomal dominant mode of inheritance.3 3 Although most persons with the May-H...